Leishmania DNA Replication Timing: A Stochastic Event?

TitleLeishmania DNA Replication Timing: A Stochastic Event?
Publication TypeJournal Article
Year of Publication2016
AuthorsRocha-Granados MC, Klingbeil MM
JournalTrends Parasitol
Volume32
Issue10
Pagination755-757
Date Published2016 10
ISSN1471-5007
KeywordsAnimals, DNA Replication Timing, Drug Delivery Systems, Genomic Instability, Humans, Leishmania, Leishmaniasis, Replication Origin
Abstract

For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner.

DOI10.1016/j.pt.2016.05.011
Alternate JournalTrends Parasitol.
PubMed ID27255527
Grant ListR21 AI126455 / AI / NIAID NIH HHS / United States