Drug resistance is a major problem that complicates the treatments of infectious diseases. It is a consequence of genetic changes in a microbe, and molecular mechanisms vary widely including mutations of target enzymes, increased expression of efflux pump, horizontal transfer of resistance gene, and induction of inactivating enzymes. While understanding the molecular mechanisms of drug resistance is critical to introduce next generation drugs, we also need effort to fill in the gap between basic science discoveries and tackling socioeconomical issues associated with drug resistance such as noncompliance of patients, overuse of antibiotics, and lack of governmental support. Is discovering new antibiotics the only thing scientists can do? How can we reduce the chances of developing drug-resistant microbes? Are we really reducing the burden of infectious diseases by introducing more antibiotics? Students will have opportunities to gain wider integral perspectives on how to tackle infectious diseases. Satisfies one of three required modules for the Integrative Experience requirement for BA-MicBio or BS-MicBio majors.
MICROBIO 494DI Drug Resistance: Molecular Mechanisms