HIV rates in U.S. poverty areas rival those found in Haiti, Burundi, Ethiopia, and Angola. HIV prevalence in high-poverty neighborhoods is more than double that of the nation overall. Within high-poverty neighborhoods, prevalence among people living below the poverty line was double that of those living above it. Blacks disproportionately bear the brunt of the HIV epidemic in the US accounting for over 48% of all new cases of the disease while representing only 12% of the population. The HIV epidemic that was once thought to be a declining problem is now threatening to destroy not only the progress previously made, but also the health, well-being and potential of men and women of all races in poverty areas across the United States. Some important questions therefore need to be answered: Is race, poverty or both the driver of HIV in these communities? What should be done to stem the tide of new HIV infections in these areas of our society? This course satisfies one of the three modules required for the Integrative Experience for BA-MicBio and BS-MicBio majors.