|Title||Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M|
|Keywords||Cryoelectron Microscopy, Cytochromes c, Electron Transport, Fimbriae, Bacterial, Geobacter, Nanowires|
Electrically conductive pili from species, termed bacterial nanowires, are intensely studied for their biological significance and potential in the development of new materials. Using cryo-electron microscopy, we have characterized nanowires from conductive pili preparations that are composed solely of head-to-tail stacked monomers of the six-heme C-type cytochrome OmcS. The unique fold of OmcS - closely wrapped around a continuous stack of hemes that can serve as an uninterrupted path for electron transport - generates a scaffold that supports the unbranched chain of hemes along the central axis of the filament. We present here, at 3.4 Å resolution, the structure of this cytochrome-based filament and discuss its possible role in long-range biological electron transport.
|Alternate Journal||Commun Biol|
|PubMed Central ID||PMC6584659|