|Leishmania DNA Replication Timing: A Stochastic Event?
|Year of Publication
|Rocha-Granados MC, Klingbeil MM
|Animals, DNA Replication Timing, Drug Delivery Systems, Genomic Instability, Humans, Leishmania, Leishmaniasis, Replication Origin
For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner.
|R21 AI126455 / AI / NIAID NIH HHS / United States