Phylogenetic classification of diverse LysR-type transcriptional regulators of a model prokaryote Geobacter sulfurreducens.

TitlePhylogenetic classification of diverse LysR-type transcriptional regulators of a model prokaryote Geobacter sulfurreducens.
Publication TypeJournal Article
Year of Publication2012
AuthorsKrushkal J, Qu Y, Lovley DR, Adkins RM
JournalJ Mol Evol
Volume74
Issue3-4
Pagination187-205
Date Published2012 Apr
ISSN1432-1432
Abstract

The protein family of LysR-type transcriptional regulators (LTTRs) is highly abundant among prokaryotes. We analyzed 10,145 non-redundant microbial sequences with homology to eight LysR family regulators of a model prokaryote, Geobacter sulfurreducens, and employed phylogenetic tree inference for LTTR classification. We also analyzed the arrangement of genome clusters containing G. sulfurreducens LTTR genes and searched for LTTR regulatory motifs, suggesting likely regulatory targets of G. sulfurreducens LTTRs. This is the first study to date providing a detailed classification of LTTRs in the deltaproteobacterial family Geobacteraceae.

DOI10.1007/s00239-012-9498-z
Alternate JournalJ. Mol. Evol.
PubMed ID22526031