The origin of antigenic diversity in Plasmodium falciparum.

TitleThe origin of antigenic diversity in Plasmodium falciparum.
Publication TypeJournal Article
Year of Publication2000
AuthorsRich SM, Ferreira MU, Ayala FJ
JournalParasitol Today
Date Published2000 Sep
KeywordsAmino Acid Sequence, Animals, Antigens, Protozoan, Base Sequence, Genes, Protozoan, Genetic Variation, Merozoite Surface Protein 1, Molecular Sequence Data, Plasmodium falciparum, Protozoan Proteins, Sequence Homology

Most studies of genetic variability of Plasmodium falciparum have focused on protein antigens and the genes that encode them. The consensus is that populations exhibit high levels of genetic polymorphism, most notably the genes encoding surface proteins of the merozoite (Msp1, Msp2) and the sporozoite (Csp). The age and derivation of this variation is a subject that warrants further careful consideration, as discussed here by Stephen Rich, Marcelo Ferreira and Francisco Ayala.

Alternate JournalParasitol. Today (Regul. Ed.)
PubMed ID10951599