The specificity of heterophil antibodies in patients and healthy donors with no or minimal signs of infectious mononucleosis.

TitleThe specificity of heterophil antibodies in patients and healthy donors with no or minimal signs of infectious mononucleosis.
Publication TypeJournal Article
Year of Publication1976
AuthorsHorwitz CA, Henle W, Henle G, Polesky H, Wexler H, Ward P
JournalBlood
Volume47
Issue1
Pagination91-8
Date Published1976 Jan
ISSN0006-4971
KeywordsAdolescent, Adult, Agglutinins, Antibodies, Heterophile, Antigens, Aspartate Aminotransferases, Capsid, Female, gamma-Glutamyltransferase, Herpesvirus 4, Human, Humans, Infectious Mononucleosis, Male, Serologic Tests
Abstract

Over several years sera were collected from 14 heterophil-positive students or patients who did not fulfill minimal hematologic criteria for infectious mononucleosis (I.M.) The specificity of these heterophil reactions for I.M. was investigated by determining antibodies to Epstein-Barr virus-determined antigens, i.e., to viral capsid antigens (VCA), early antigens (EA), and EBV-associated nuclear antigens (EBNA). On the basis of detectable anti-EA and/or the early absence and late emergence of anti-EBNA, four of these 14 individuals showed evidence of a current or very recent primary Epstein-Barr virus infection. The other ten patients showed antibody patterns indicative of Epstein-Barr virus infections in the past, and no firm conclusions could be drawn with regard to the specificity of their heterophil reactions. It was assumed, however, that some represented atypical clinical forms of EBV infection and that timing of specimen collection was a factor in explaining the paucity of Downey cells. In three patients, the absorbed heterophil-positive reactions persisted with little change in titer for at least 22 mo and thus might represent false-positive tests.

Alternate JournalBlood
PubMed ID1126