New bactericidal surgical suture coating.

TitleNew bactericidal surgical suture coating.
Publication TypeJournal Article
Year of Publication2012
AuthorsLi Y, Kumar KN, Dabkowski JM, Corrigan M, Scott RW, Nüsslein K, Tew GN
JournalLangmuir
Volume28
Issue33
Pagination12134-9
Date Published2012 Aug 21
ISSN1520-5827
Abstract

This paper demonstrates the effectiveness of a new antimicrobial suture coating. An amphiphilic polymer, poly[(aminoethyl methacrylate)-co-(butyl methacrylate)] (PAMBM), inspired by antimicrobial peptides, was bactericidal against S. aureus in time-kill experiments. PAMBM was then evaluated in a variety of polymer blends using the Japanese Industrial Standard (JIS) method and showed excellent antimicrobial activity at a low concentration (0.5 wt %). Using a similar antimicrobial coating formula to commercial Vicryl Plus sutures, disk samples of the coating material containing PAMBM effectively killed bacteria (98% reduction at 0.75 wt %). Triclosan, the active ingredient in Vicryl Plus coatings, did not kill the bacteria. Further Kirby-Bauer assays of these disk samples showed an increasing zone of inhibition with increasing concentration of PAMBM. Finally, the PAMBM-containing coating was applied to sutures, and the morphology of the coating surface was characterized by SEM, along with Vicryl and uncoated sutures. The PAMBM-containing sutures killed bacteria more effectively (3 log(10) reduction at 2.4 wt %) than Vicryl Plus sutures (0.5 log(10) reduction).

DOI10.1021/la302732w
Alternate JournalLangmuir
PubMed ID22877364